From North:

A14 exit Ortona: turn left direction Ortona, go straight to S.Leonardo then S.Apollinare


or:

A14 exit Ortona: turn left then again left until "SS16" towards S.Vito Marina, then go up on the right to S.Apollinare

from South:

A14 exit Val di Sangro, go on your right towards "SS16" going north until S.Vito Marina, then go up on the left towards "S.Apollinare-Lanciano".